acmg-variant-classifier
ACMG/AMP variant classification skill for systematic pathogenicity assessment
Best use case
acmg-variant-classifier is best used when you need a repeatable AI agent workflow instead of a one-off prompt.
ACMG/AMP variant classification skill for systematic pathogenicity assessment
Teams using acmg-variant-classifier should expect a more consistent output, faster repeated execution, less prompt rewriting.
When to use this skill
- You want a reusable workflow that can be run more than once with consistent structure.
When not to use this skill
- You only need a quick one-off answer and do not need a reusable workflow.
- You cannot install or maintain the underlying files, dependencies, or repository context.
Installation
Claude Code / Cursor / Codex
Manual Installation
- Download SKILL.md from GitHub
- Place it in
.claude/skills/acmg-variant-classifier/SKILL.mdinside your project - Restart your AI agent — it will auto-discover the skill
How acmg-variant-classifier Compares
| Feature / Agent | acmg-variant-classifier | Standard Approach |
|---|---|---|
| Platform Support | Not specified | Limited / Varies |
| Context Awareness | High | Baseline |
| Installation Complexity | Unknown | N/A |
Frequently Asked Questions
What does this skill do?
ACMG/AMP variant classification skill for systematic pathogenicity assessment
Where can I find the source code?
You can find the source code on GitHub using the link provided at the top of the page.
SKILL.md Source
# ACMG Variant Classifier Skill ## Purpose Enable ACMG/AMP variant classification for systematic pathogenicity assessment following clinical guidelines. ## Capabilities - Automated evidence criteria application - Population frequency filtering - In silico prediction integration - Literature evidence curation - Inheritance pattern analysis - Classification report generation ## Usage Guidelines - Apply ACMG criteria systematically - Document evidence for each criterion - Consider inheritance patterns in assessment - Review literature for supporting evidence - Generate clear classification reports - Track classification changes over time ## Dependencies - InterVar - VarSome API - ClinVar ## Process Integration - Clinical Variant Interpretation (clinical-variant-interpretation) - Rare Disease Diagnostic Pipeline (rare-disease-diagnostics) - Newborn Screening Genomics (newborn-screening-genomics)
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