prospero-registration-helper

Assists researchers in generating INPLASY registration content for meta-analyses from a title and optional protocol. Use when the user wants to draft a INPLASY registration form.

Organize requirements into Markdown/JSON mind map structures; use when you need a hierarchical outline for mind map tools (e.g., XMind, ProcessOn, FreeMind) or for documentation planning.

A comprehensive auditor for any agent skill — including Manus, OpenClaw/ClawHub, Claude, LobeHub, or custom SKILL.md-based skills. Use this skill whenever a user wants to evaluate, audit, review, score, or quality-check an agent skill before publishing, updating, or deploying. Covers two hard veto gates (structural redlines + research integrity redlines), static quality scoring across 25 criteria (ISO 25010 + OpenSSF + Agent), dynamic test input generation, multi-mode execution testing, multi-layer output evaluation with five specialized category rubrics (Evidence Insight / Protocol Design / Data Analysis / Academic Writing / Other), a Research Veto that applies to all four research categories, human eval viewer generation, actionable P0/P1/P2 optimization recommendations, and automatic skill improvement that outputs a polished, production-ready SKILL.md. Also use whenever a user says "audit my skill", "evaluate my skill", "improve my skill", or wants a corrected version after evaluation.

Generates complete two-sample Mendelian randomization (MR) research designs from a user-provided research direction. Use when users want to design, plan, or build a study using two-sample MR to test causal relationships. Triggers:"design a two-sample MR study", "build a publishable MR paper", "test whether this biomarker causally affects this disease", "generate Lite/Standard/Advanced MR plans", "screen multiple exposures with MR", "bidirectional MR design", "causal inference using GWAS summary statistics", or "I want to study X and Y using MR". Always outputs four workload configurations (Lite / Standard / Advanced / Publication+) with a recommended primary plan, step-by-step workflow, figure plan, validation strategy, minimal executable version, and publication upgrade path.

Generates a comprehensive research proposal design based on input literature, including hypothesis, mechanism verification, and budget. Use when the user wants to design a research project from a paper.

Write competitive research proposals for NSF, NIH, DOE, DARPA, and Taiwan's NSTC when you need agency-compliant narratives, budgets, and review-criteria alignment for a specific solicitation/FOA/BAA.

Standardize fragmented experimental steps into reproducible protocol documents when you need method organization, lab SOP drafting, or cross-operator reproducibility; missing parameters must be explicitly marked as "To be supplemented/Not provided".

Generates complete non-tumor biomedical machine learning research designs from a user-provided research direction. Always use this skill when users want to plan bioinformatics + ML papers for non-cancer diseases (metabolic, cardiovascular, kidney, inflammatory, autoimmune, infectious, neurological, endocrine, wound healing, chronic multifactor), design diagnostic biomarker studies, combine GEO datasets with feature selection and ML modeling, or generate Lite/Standard/Advanced/Publication+ workload plans. Trigger for:"non-tumor ML study", "bioinformatics paper outside oncology", "key genes and diagnostic model for a disease", "pyroptosis/ferroptosis/senescence/autophagy + disease", "GEO datasets + machine learning", "RF + LASSO diagnostic model", "DEG + feature selection + validation", "immune infiltration + biomarker", "non-cancer biomarker paper". Trigger even for casual phrasings like "I want to study X using machine learning", "help me design a non-tumor bioinformatics paper", or "how do I build a diagnostic model for disease Y".

Generates complete network toxicology + molecular docking research designs from a user-provided toxicant and disease/phenotype. Always use this skill when users want to investigate how an environmental toxicant, endocrine disruptor, heavy metal, food contaminant, pharmaceutical residue, or consumer product chemical may contribute to a disease through shared molecular targets, hub genes, pathways, and docking evidence. Trigger for:"network toxicology study", "toxicology mechanism paper", "target prediction + PPI + docking", "environmental pollutant and disease mechanism", "hub genes and docking for toxicant", "Lite/Standard/Advanced toxicology plan", "CTD + SwissTargetPrediction + GeneCards + STRING", "CB-Dock2 docking study", "triclosan/BPA/cadmium/PFAS + disease". Also triggers for Chinese phrasings:"网络毒理学研究设计"、"毒物机制论文"、"靶点预测+PPI+对接"、"环境污染物与疾病机制". Trigger even for casual phrasings like "I want to study how chemical X affects disease Y" or "help me design a toxicology paper". Always output four workload configurations (Lite / Standard / Advanced / Publication+) with a recommended primary plan, step-by-step workflow, figure plan, validation strategy, minimal executable version, and publication upgrade path.

Generates a PROSPERO-compliant Meta-analysis protocol based on Title and PICOS. Use when the user wants to write a protocol for a systematic review or meta-analysis.

Structured scientific hypothesis formulation from observations; use when you have experimental observations or preliminary data and need testable hypotheses with predictions, mechanisms, and validation experiments.

Automated LLM-driven hypothesis generation and testing for tabular datasets; use when you need systematic exploration of empirical patterns (e.g., fraud detection, content analysis) and want to combine literature insights with data-driven hypothesis evaluation.