research-hotspot-analysis

Generates complete two-sample Mendelian randomization (MR) research designs from a user-provided research direction. Use when users want to design, plan, or build a study using two-sample MR to test causal relationships. Triggers:"design a two-sample MR study", "build a publishable MR paper", "test whether this biomarker causally affects this disease", "generate Lite/Standard/Advanced MR plans", "screen multiple exposures with MR", "bidirectional MR design", "causal inference using GWAS summary statistics", or "I want to study X and Y using MR". Always outputs four workload configurations (Lite / Standard / Advanced / Publication+) with a recommended primary plan, step-by-step workflow, figure plan, validation strategy, minimal executable version, and publication upgrade path.

Generates a comprehensive research proposal design based on input literature, including hypothesis, mechanism verification, and budget. Use when the user wants to design a research project from a paper.

Write competitive research proposals for NSF, NIH, DOE, DARPA, and Taiwan's NSTC when you need agency-compliant narratives, budgets, and review-criteria alignment for a specific solicitation/FOA/BAA.

Generates complete non-tumor biomedical machine learning research designs from a user-provided research direction. Always use this skill when users want to plan bioinformatics + ML papers for non-cancer diseases (metabolic, cardiovascular, kidney, inflammatory, autoimmune, infectious, neurological, endocrine, wound healing, chronic multifactor), design diagnostic biomarker studies, combine GEO datasets with feature selection and ML modeling, or generate Lite/Standard/Advanced/Publication+ workload plans. Trigger for:"non-tumor ML study", "bioinformatics paper outside oncology", "key genes and diagnostic model for a disease", "pyroptosis/ferroptosis/senescence/autophagy + disease", "GEO datasets + machine learning", "RF + LASSO diagnostic model", "DEG + feature selection + validation", "immune infiltration + biomarker", "non-cancer biomarker paper". Trigger even for casual phrasings like "I want to study X using machine learning", "help me design a non-tumor bioinformatics paper", or "how do I build a diagnostic model for disease Y".

Generates complete network toxicology + molecular docking research designs from a user-provided toxicant and disease/phenotype. Always use this skill when users want to investigate how an environmental toxicant, endocrine disruptor, heavy metal, food contaminant, pharmaceutical residue, or consumer product chemical may contribute to a disease through shared molecular targets, hub genes, pathways, and docking evidence. Trigger for:"network toxicology study", "toxicology mechanism paper", "target prediction + PPI + docking", "environmental pollutant and disease mechanism", "hub genes and docking for toxicant", "Lite/Standard/Advanced toxicology plan", "CTD + SwissTargetPrediction + GeneCards + STRING", "CB-Dock2 docking study", "triclosan/BPA/cadmium/PFAS + disease". Also triggers for Chinese phrasings:"网络毒理学研究设计"、"毒物机制论文"、"靶点预测+PPI+对接"、"环境污染物与疾病机制". Trigger even for casual phrasings like "I want to study how chemical X affects disease Y" or "help me design a toxicology paper". Always output four workload configurations (Lite / Standard / Advanced / Publication+) with a recommended primary plan, step-by-step workflow, figure plan, validation strategy, minimal executable version, and publication upgrade path.

Generates a structured prompt framework for clinical study protocols. Supports Diagnostic, Efficacy, Etiology, and Prognosis studies. Calculates sample size and provides logic guides for LLMs.

A biomedical research topic designer that generates progressive experimental subtitles and detailed research outlines based on a given subject. Use when the user wants to design a research proposal, outline experiments for a topic, or structure a biomedical study.

Generates professional market research reports by analyzing business intent, decision levels, and conducting multi-source data retrieval (Web, PubMed, Clinical Trials).

Download academic papers from open-access sources when the user provides a DOI/arXiv ID or requests a keyword-based paper search, and return the saved PDF path.

Generates a weekly academic literature report based on keywords using PubMed. Use when the user wants to track recent research progress on a specific topic, automatically retrieving, classifying, and summarizing relevant papers from the last 7 days.

Kaplan-Meier survival analysis tool for clinical and biological research. Generates publication-ready survival curves with statistical tests.

Guided statistical analysis for test selection, assumption checks, power analysis, and APA-style reporting. Use when you need to choose an appropriate statistical test for your data and produce publication-ready results (including effect sizes and diagnostics).