samtools-bam-processor

BAM/SAM file manipulation skill for sorting, indexing, filtering, and extracting alignment data

509 stars

Best use case

samtools-bam-processor is best used when you need a repeatable AI agent workflow instead of a one-off prompt.

BAM/SAM file manipulation skill for sorting, indexing, filtering, and extracting alignment data

Teams using samtools-bam-processor should expect a more consistent output, faster repeated execution, less prompt rewriting.

When to use this skill

  • You want a reusable workflow that can be run more than once with consistent structure.

When not to use this skill

  • You only need a quick one-off answer and do not need a reusable workflow.
  • You cannot install or maintain the underlying files, dependencies, or repository context.

Installation

Claude Code / Cursor / Codex

$curl -o ~/.claude/skills/samtools-bam-processor/SKILL.md --create-dirs "https://raw.githubusercontent.com/a5c-ai/babysitter/main/library/specializations/domains/science/bioinformatics/skills/samtools-bam-processor/SKILL.md"

Manual Installation

  1. Download SKILL.md from GitHub
  2. Place it in .claude/skills/samtools-bam-processor/SKILL.md inside your project
  3. Restart your AI agent — it will auto-discover the skill

How samtools-bam-processor Compares

Feature / Agentsamtools-bam-processorStandard Approach
Platform SupportNot specifiedLimited / Varies
Context Awareness High Baseline
Installation ComplexityUnknownN/A

Frequently Asked Questions

What does this skill do?

BAM/SAM file manipulation skill for sorting, indexing, filtering, and extracting alignment data

Where can I find the source code?

You can find the source code on GitHub using the link provided at the top of the page.

SKILL.md Source

# Samtools BAM Processor Skill

## Purpose
Provide BAM/SAM file manipulation capabilities for sorting, indexing, filtering, and extracting alignment data.

## Capabilities
- BAM sorting and indexing
- Duplicate marking and removal
- Alignment statistics generation
- Region extraction and filtering
- Read group management
- Format conversion (SAM/BAM/CRAM)

## Usage Guidelines
- Sort and index BAM files for efficient access
- Mark or remove duplicates based on protocol
- Generate alignment statistics for quality assessment
- Extract regions of interest for targeted analysis
- Manage read groups for multi-sample data
- Use CRAM for storage efficiency

## Dependencies
- samtools
- Picard
- sambamba

## Process Integration
- Whole Genome Sequencing Pipeline (wgs-analysis-pipeline)
- Tumor Molecular Profiling (tumor-molecular-profiling)
- RNA-seq Differential Expression Analysis (rnaseq-differential-expression)

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